Nicotinamide Riboside benefits

Nicotinamide Riboside is gaining increasing attention in the world of vitality and healthy aging. This form of vitamin B3 helps the body produce NAD+, a substance involved in energy production, cell repair, and metabolism. As you get older, NAD+ levels in your body decline. This can affect your energy level and the way your cells function. In this article, you’ll read what Nicotinamide Riboside is, what benefits are associated with it, and why more and more people are choosing an NR supplement.

What does a Nicotinamide Riboside supplement do?

Nicotinamide Riboside (NR) is a form of vitamin B3. Your body uses this substance to produce NAD+. NAD+ is a coenzyme found in every living cell. It plays a role in converting food into energy and repairing damaged DNA. As you get older, NAD+ levels in your cells decline. This process is linked to cellular aging and a decrease in vitality. By taking a Nicotinamide Riboside supplement, you help your body replenish this supply.

Nicotinamide benefits: what is it good for?

Science is conducting extensive research into the effects of increased NAD+ levels. The focus is on energy, the brain, and healthy aging. Below are the key findings from recent studies.
NR may possibly help with fatigue

Early research³ shows positive results when studying fatigue-related processes. This suggests that NR has potential as a topic for further research in people with low energy levels. The available literature offers insight into how the substance may support physical fitness, but more human research is needed to draw conclusions.

NR appears to support psychological functioning

In the scientific literature, indications can be found that NR may have a positive effect on psychological functioning. For example, research⁴ looks at inflammatory markers in the brain and cognitive functions such as memory. This points to a possible role in reducing neuroinflammation, although direct evidence in humans is currently still limited.

NR may help support normal energy metabolism

In a double-blind study⁵ in healthy older adults, participants took 1 gram of NR daily for 21 days. The results showed an increase in NAD+ metabolites in skeletal muscle. Researchers also observed a decrease in inflammatory markers in the blood. This contributes to insight into how NR may support the body’s energy balance.

NR may have a positive influence on nervous system function

The functioning of the nervous system depends on sufficient cellular energy. Scientific research⁶ shows that NR effectively increases NAD+ levels. This offers a possible mechanism for supporting nerve cells, although further research is needed to fully understand its practical significance.

NR appears to be good for the skin

Studies⁷ suggest that NR may affect NAD+ levels in the skin. This may support the cells’ natural DNA repair. Researchers are also investigating how it may help protect the skin from oxidative stress caused by UV radiation. These processes are linked to signs of skin aging, although the results are preliminary.

NR seems to activate enzymes that are important for healthy aging
Enzymes are proteins that speed up chemical reactions in the body. Nicotinamide Riboside is associated with the activation of specific enzymes called sirtuins. Sirtuins need NAD+ to do their work. These enzymes are involved in processes that protect cells from aging and damage. By supporting your NAD+ level, you may help these enzymes keep your cells healthy.

NR appears to increase vitamin B3 levels

Your body needs vitamin B3 for metabolism. The body can produce this vitamin itself from tryptophan, an amino acid from food. NR is a form of vitamin B3 and contributes to the production of higher NAD+ levels. This may benefit overall vitality.

NR may help protect brain cells

NAD+ is involved in regulating the protein PGC-1 alpha. This protein plays a role in protecting cells against oxidative stress. When there are too many free radicals in the body, tissue damage occurs. Oxidative stress appears to play a role in processes that contribute to aging and neurodegeneration. Research suggests that a higher NAD+ level may help slow these processes in the brain, although more research is needed.

NR could support liver function

A central organ for energy metabolism is the liver. The production of NAD+ is associated with supporting the liver and the function of mitochondria, the cell’s energy factories. Research is looking at how the liver processes waste products and regulates fat metabolism.

Buy Nicotinamide Riboside at EnduraVita

Want to experience the benefits of this supplement for yourself? At Enduravita, you can buy a high-quality Nicotinamide Riboside supplement. All supplements in our range meet the strictest safety standards. This way, you can be sure you’ll receive a pure product that supports your body optimally.

Improve your vitality with Nicotinamide Riboside

The use of Nicotinamide Riboside is being studied scientifically in relation to energy, cellular health, and aging. The increase in NAD+ levels is associated with processes such as DNA repair and energy metabolism. Although much research is promising, we always recommend seeking medical advice before starting supplements. This is especially important if you are already using medication or have health complaints.

Ready to give your vitality sustainable support? View our range and order your supplements today.

1 Chen, A. C., Martin, A. J., Choy, B., Fernandez-Peñas, P., Dalziell, R. A., Halliday, G. M., ... & Damian, D. L. (2015). A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention. https://doi.org/10.1056/nejmoa1506197 

2 Mainville, L., Smilga, A., Forting, P. R. (2022). Effect of Nicotinamide in Skin Cancer and Actinic Keratoses Chemoprophylaxis, and Adverse Effects Related to Nicotinamide: A Systematic Review and Meta-Analysis.  
https://journals.sagepub.com/doi/10.1177/12034754221078201 

3 Joshi, U., Evans, J. E., Pearson, A. (2020). Targeting sirtuin activity with nicotinamide riboside reduces neuroinflammation in a GWI mouse model.
https://www.sciencedirect.com/science/article/abs/pii/S0161813X20300656 

4Lee, H. J., Yang, S. J. (2019). Supplementation with Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice. https://pubmed.ncbi.nlm.nih.gov/31461911/ 

5 Elhassan, Y. S., Kluckova, K., Fletcher, R. S. (2019). Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.
https://www.sciencedirect.com/science/article/pii/S2211124719309404 

6 Fricker, R. A., Green, E. L., Jenkins, S. I., Griffin, S. M. (2018). The Influence of Nicotinamide on Health and Disease in the Central Nervous System.
 https://pmc.ncbi.nlm.nih.gov/articles/PMC5966847/ 

7 Dognay, S., Budak, O., Sahin, A., Bahtiyar, N. (2022). Antioxidant and Anti-Infl ammatory Eff ects of Nicotinamide Adenine Dinucleotide (NAD+) Against Acute Hepatorenal Oxidative Injury in An Experimental Sepsis Model. https://vetdergikafkas.org/uploads/pdf/pdf_KVFD_2880.pdf